CONDENSED CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands	6 Months Ended
	Jun. 30, 2020	Jun. 30, 2019
Cash flows from operating activities:
Net loss	$ (353,871)	$ (273,374)
Adjustments to reconcile net loss to net cash used in operating activities:
Non-cash share-based compensation expense	28,641	24,884
Non-cash interest expense on mandatorily redeemable preferred shares	12,554	3,955
Non-cash interest expense on liability related to sale of future royalties	19,995	11,972
Change in fair value of derivative liability	5,131	1,263
Loss from equity method investment	2,865	2,315
Other non-cash items	1,701	271
Changes in operating assets and liabilities:
Trade receivables, net	(44,796)	0
Inventories	(6,931)	0
Prepaid expenses and other current assets	(34,380)	(523)
Other assets	17	(21)
Accounts payable	934	2,117
Accrued expenses and other current liabilities	41,543	22,385
Other long-term liabilities	62	(2,000)
Net cash used in operating activities	(326,535)	(206,756)
Cash flows from investing activities:
Purchases of property and equipment	(1,381)	(1,448)
Payments for leasehold improvements	(1,600)	0
Payments for intangible assets	(21,500)	0
Net cash used in investing activities	(24,481)	(1,448)
Cash flows from financing activities:
Proceeds from issuance of common shares	283,333	282,000
Proceeds from issuance of mandatorily redeemable preferred shares	0	125,000
Proceeds from exercise of warrants	0	1,998
Payments of issuance costs	(500)	(517)
Proceeds from exercise of stock options	14,355	1,213
Repayment of principal for finance leases	(37)	0
Net cash provided by financing activities	297,151	409,694
Net increase (decrease) in cash and restricted cash	(53,865)	201,490
Cash and restricted cash at beginning of period	317,727	264,249
Cash and restricted cash at end of period	263,862	465,739
Supplemental disclosure of cash flow information:
Cash paid for interest	0	0
Cash paid for income taxes	$ 0	$ 428