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Shareholders' Equity (Tables)
3 Months Ended
Mar. 31, 2020
Stockholders' Equity Note [Abstract]  
Schedule of changes in shareholders' equity
Changes in shareholders’ equity for the three months ended March 31, 2020 were as follows:
Common Shares
SharesAmountAdditional Paid-in CapitalAccumulated DeficitTotal Shareholders' Equity (Deficit)
Balance as of December 31, 201952,385,283  $881,426  $83,523  $(972,373) $(7,424) 
Issuance of common shares, net of offering costs5,555,554  282,833  —  —  282,833  
Issuance of common shares under equity incentive plan447,111  10,880  (8,273) —  2,607  
Non-cash share-based compensation expense—  —  16,879  —  16,879  
Net loss—  —  —  (172,937) (172,937) 
Balance as of March 31, 202058,387,948  $1,175,139  $92,129  $(1,145,310) $121,958  
Changes in shareholders’ equity for the three months ended March 31, 2019 were as follows:
Common Shares
SharesAmountAdditional Paid-in CapitalAccumulated DeficitTotal Shareholders' Equity (Deficit)
Balance as of December 31, 201844,197,549  $554,384  $40,104  $(443,568) $150,920  
Issuance of common shares under equity incentive plan85,445  1,961  (896) —  1,065  
Non-cash share-based compensation expense—  —  7,330  —  7,330  
Net loss—  —  —  (62,304) (62,304) 
Balance as of March 31, 201944,282,994  $556,345  $46,538  $(505,872) $97,011