CONDENSED CONSOLIDATED BALANCE SHEETS - USD ($) $ in Thousands	Mar. 31, 2019	Dec. 31, 2018
Current assets:
Cash	$ 217,407	$ 264,249
Prepaid expenses and other current assets	9,966	8,090
Total current assets	227,373	272,339
Property and equipment, net	7,157	6,248
Equity method investment	10,514	11,414
Other assets	36	11
Total assets	245,080	290,012
Current liabilities:
Accounts payable	8,210	10,752
Accrued expenses	15,483	8,782
Total current liabilities	23,693	19,534
Liability related to sale of future royalties	124,332	117,515
Other long-term liabilities	44	2,043
Total liabilities	148,069	139,092
Commitments and contingencies
Shareholders’ equity:
Common shares, no par value; 200,000,000 shares authorized as of March 31, 2019 and December 31, 2018; 44,282,994 and 44,197,549 shares issued and outstanding as of March 31, 2019 and December 31, 2018, respectively	556,345	554,384
Additional paid-in capital	46,538	40,104
Accumulated deficit	(505,872)	(443,568)
Total shareholders’ equity	97,011	150,920
Total liabilities and shareholders’ equity	$ 245,080	$ 290,012