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Related Party Transactions (Details)
1 Months Ended 3 Months Ended 6 Months Ended
Jan. 26, 2017
$ / shares
shares
Aug. 29, 2016
director
Sep. 30, 2013
USD ($)
shares
Mar. 31, 2018
USD ($)
Jun. 30, 2018
USD ($)
Jun. 30, 2017
USD ($)
Jun. 30, 2018
USD ($)
Jun. 30, 2017
USD ($)
Jan. 31, 2018
shares
Dec. 31, 2017
USD ($)
Related Party Transactions                    
Common stock value         $ 413,225,000   $ 413,225,000     $ 311,061,000
Cash payment for purchase of equity method investment             1,375,000 $ 2,999,000    
Chief Executive Officer | License Agreement with Yale                    
Related Party Transactions                    
Common shares issued | shares     250,000              
Percent of Company's outstanding equity fully diluted     5.10%              
Common stock value     $ 152,000              
Expenses under related party agreement         0 $ 0 0 $ 0    
Payments due to related party         $ 0   0     $ 0
Payment received from related party       $ 600,000            
Shareholders and members of the Board of Directors | Guarantor and Co-Guarantor Warrants | Guarantor and Co-Guarantor Warrants                    
Related Party Transactions                    
Common shares issued | shares 107,500                  
Exercise price of warrants (per share) | $ / shares $ 9.2911                  
Equity Investment | Kleo Pharmaceuticals, Inc.                    
Related Party Transactions                    
Number to designate to Kleo's board of directors | director   2                
Shares purchased in equal tranches (shares) | shares                 1,375,000  
Cash payment for purchase of equity method investment             $ 1,375,000