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License and Other Agreements (Details) - USD ($)
$ in Thousands
1 Months Ended
Mar. 31, 2018
Jan. 31, 2018
Catalent Agreement | Collaborative arrangement    
License and other agreements    
Last patent right expiration period   10 years
Automatic extension period   1 year
Catalent Agreement | Collaborative arrangement | Maximum    
License and other agreements    
Milestone payment to be paid   $ 1,500
BMS Agreement    
License and other agreements    
Upfront payment under the BMS Amendment $ 50,000