Shareholders' Equity (Tables)

6 Months Ended

Jun. 30, 2018

Stockholders' Equity Note [Abstract]

Schedule of changes in shareholders' equity

Changes in shareholders’ equity for the six months ended June 30, 2018 and 2017 were as follows:

	Six Months Ended June 30,
	2018			2017
Balances as of December 31, 2017 and 2016	$	131,971		$	(45,033	)
Beneficial conversion feature on Series A preferred shares	—			12,006
Accretion of beneficial conversion feature on Series A preferred shares	—			(12,006		)
Issuance of common shares as payment for equity investment	—			352
Conversion of convertible preferred shares to common shares	—			81,936
Issuance of common shares in settlement of contingent equity liability	—			32,020
Issuance of common shares upon completion of initial public offering, net of offering costs	—			176,128
Issuance of common share warrant as consideration for services	—			93
Issuance of common shares upon completion of private placement equity offerings, net of offering costs	95,855			—
Reclassification of warrant liability to equity	5,203			—
Exercise of stock options	1,836			—
Share-based compensation expense	8,696			4,549
Net loss	(124,731		)	(57,193		)
Balances as of June 30, 2018 and 2017	$	118,830		$	192,852