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Related Party Transactions (Details)
$ / shares in Units, $ in Thousands
1 Months Ended 3 Months Ended
Jan. 26, 2017
$ / shares
shares
Aug. 29, 2016
director
$ / shares
shares
Sep. 30, 2013
USD ($)
item
shares
Jan. 31, 2018
USD ($)
shares
Mar. 31, 2018
USD ($)
Mar. 31, 2017
USD ($)
Dec. 31, 2017
USD ($)
Related Party Transactions              
Common stock value         $ 367,730   $ 311,061
Cash payment for purchase of equity method investment         1,375 $ 1,624  
Chief Executive Officer | License Agreement with Yale              
Related Party Transactions              
Number of inventors of the patents licensed from Yale | item     1        
Common shares issued | shares     250,000        
Percent of Company's outstanding equity fully diluted     5.10%        
Common stock value     $ 152        
Payments to related party         0   $ 0
Payment received from related party         $ 600    
Shareholders and members of the Board of Directors | Guarantor and Co-Guarantor Warrants | Guarantor and Co-Guarantor Warrants              
Related Party Transactions              
Common shares issued | shares 107,500            
Exercise price of warrants (per share) | $ / shares $ 9.2911            
Equity Investment | Kleo Pharmaceuticals, Inc.              
Related Party Transactions              
Shares of Kleo common stock purchased | shares   3,000,000          
Price per share | $ / shares   $ 1.00          
Additional shares of Kleo common stock purchased | shares   5,500,000          
Number to designate to Kleo's board of directors | director   2          
Shares purchased in equal tranches | shares       1,375,000      
Cash payment for purchase of equity method investment       $ 1,375