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License Agreements - Catalent Agreement (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Mar. 31, 2015
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
License agreements          
Research and development   $ 34,996 $ 27,045 $ 66,755 $ 35,137
Catalent Agreement | Collaborative arrangement          
License agreements          
Last patent right expiration period 10 years        
Automatic extension period 1 year        
Research and development   $ 0 $ 0 $ 0 $ 0
Catalent Agreement | Collaborative arrangement | Maximum          
License agreements          
Milestone payment to be paid $ 1,575