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License Agreements - MGH Agreement (Details) - USD ($)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Sep. 30, 2014
Sep. 30, 2017
Sep. 30, 2016
Sep. 30, 2017
Sep. 30, 2016
License agreements          
Research and development   $ 34,996 $ 27,045 $ 66,755 $ 35,137
MGH Agreement | Collaborative arrangement          
License agreements          
Research and development   $ 30 $ 0 $ 31 $ 5
MGH Agreement | Collaborative arrangement | Maximum          
License agreements          
License maintenance fees $ 50        
Milestone payment to be paid 750        
Commercial milestone payment to be paid $ 2,500        
Extension of due diligence requirements 1 year        
Amount of payment subject to due diligence extension $ 300        
MGH Agreement | Collaborative arrangement | Minimum          
License agreements          
License maintenance fees $ 30