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License Agreements - Yale Agreement (Details)
$ in Thousands
1 Months Ended 3 Months Ended 9 Months Ended
Feb. 29, 2016
USD ($)
shares
Sep. 30, 2013
USD ($)
item
shares
Sep. 30, 2017
USD ($)
Sep. 30, 2016
USD ($)
Jul. 31, 2016
USD ($)
shares
Sep. 30, 2017
USD ($)
Sep. 30, 2016
USD ($)
Oct. 31, 2017
USD ($)
Dec. 31, 2016
USD ($)
Jul. 31, 2015
USD ($)
Jan. 31, 2014
USD ($)
License agreements                      
Issuance of common shares | shares 429,000       1,090,500            
Investment $ 2,980       $ 8,299   $ 11,399        
Fair value of derivative liability     $ 0     $ 0   $ 0 $ 512    
Research and development     34,996 $ 27,045   66,755 35,137        
Yale Agreement | Collaborative arrangement                      
License agreements                      
Issuance of common shares | shares   250,000                  
Number of financings with institutional investors | item   2                  
Fair value of obligation   $ 0 0     0     512 $ 0 $ 0
Percentage of dollar value of all initial and future consideration   5                  
Consideration payable upon change-of-control event   $ 1,500                  
Fair value of derivative liability               $ 0      
Other income (expense) for change in the fair value of the derivative liability     0 (129)   512 (105)        
Fair value of derivative liability   0 0     0     $ 512 $ 0 $ 0
Minimum milestone payment to be paid   $ 1,000                  
Notice period to Yale to terminate the Yale Agreement   90 days                  
Last patent right expiration period   10 years                  
Research and development     $ 32 $ 0   $ 38 $ 4        
Yale Agreement | Collaborative arrangement | Maximum                      
License agreements                      
Right to purchase securities in specified future equity offering (as a percent)   10                  
Company's fully diluted common shares outstanding (as a percent)   1                  
Milestone payment to be paid   $ 2,000                  
Extension of due diligence requirements   1 year                  
Amount of payment subject to due diligence extension   $ 150                  
Yale Agreement | Collaborative arrangement | Minimum                      
License agreements                      
Investment   $ 3,500                  
Yale's ownership percentage   1.00%               1.00% 1.00%