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License Agreements - Yale Agreement (Details)
$ in Thousands
1 Months Ended 3 Months Ended
Feb. 29, 2016
USD ($)
shares
Sep. 30, 2013
USD ($)
item
shares
Mar. 31, 2017
USD ($)
Jul. 31, 2016
USD ($)
shares
Mar. 31, 2016
USD ($)
Dec. 31, 2016
USD ($)
Jul. 31, 2015
USD ($)
Jan. 31, 2014
USD ($)
License agreements                
Issuance of common shares | shares 429,000     1,090,500        
Investment $ 2,980     $ 8,299 $ 3,003      
Research and development     $ 10,740   2,370      
Yale Agreement | Collaborative arrangement                
License agreements                
Issuance of common shares | shares   250,000            
Number of financings with institutional investors | item   2            
Fair value of obligation   $ 0 223     $ 512 $ 0 $ 0
Percentage of dollar value of all initial and future consideration   5            
Consideration payable upon change-of-control event   $ 1,500            
Other expense for change in the fair value of the derivative liability     289   $ 3      
Fair value of derivative liability   0 223     $ 512 $ 0 $ 0
Minimum milestone payment to be paid   $ 1,000            
Notice period to Yale to terminate the Yale Agreement   90 days            
Last patent right expiration period   10 years            
Research and development     $ 3          
Yale Agreement | Collaborative arrangement | Maximum                
License agreements                
Right to purchase securities in specified future equity offering (as a percent)   10            
Company's fully diluted common shares outstanding (as a percent)   1            
Milestone payment to be paid   $ 2,000            
Extension of due diligence requirements   1 year            
Amount of payment subject to due diligence extension   $ 150            
Yale Agreement | Collaborative arrangement | Minimum                
License agreements                
Investment   $ 3,500            
Yale's ownership percentage   1.00%         1.00% 1.00%