144 0001689757 XXXXXXXX LIVE 0001124140 EXACT SCIENCES CORP 001-35092 5505 ENDEAVOR LANE MADISON WI 53719 608-284-5700 Elliott Jeffrey Thomas Officer Common Fidelity Brokerage Services LLC

900 Salem Street Smithfield RI 02917

30210 2505013.20 180665327 08/21/2023 NASDAQ Common 04/30/2021 ESPP Purchase Issuer N 206 04/30/2021 Cash Common 02/14/2022 Restricted Stock Vesting Issuer N 2133 02/14/2022 Compensation Common 02/15/2022 Restricted Stock Vesting Issuer N 361 02/15/2022 Compensation Common 02/19/2022 Restricted Stock Vesting Issuer N 1555 02/19/2022 Compensation Common 02/23/2022 Restricted Stock Vesting Issuer N 6850 02/23/2022 Compensation Common 02/26/2022 Restricted Stock Vesting Issuer N 1792 02/26/2022 Compensation Common 02/27/2022 Restricted Stock Vesting Issuer N 2620 02/27/2022 Compensation Common 03/15/2022 Restricted Stock Vesting Issuer N 361 03/15/2022 Compensation Common 04/15/2022 Restricted Stock Vesting Issuer N 361 04/15/2022 Compensation Common 05/02/2022 ESPP Purchase Issuer N 260 05/02/2022 Cash Common 05/15/2022 Restricted Stock Vesting Issuer N 361 05/15/2022 Compensation Common 06/15/2022 Restricted Stock Vesting Issuer N 361 06/15/2022 Compensation Common 07/15/2022 Restricted Stock Vesting Issuer N 361 07/15/2022 Compensation Common 08/15/2022 Restricted Stock Vesting Issuer N 361 08/15/2022 Compensation Common 09/15/2022 Restricted Stock Vesting Issuer N 361 09/15/2022 Compensation Common 10/15/2022 Restricted Stock Vesting Issuer N 361 10/15/2022 Compensation Common 11/15/2022 Restricted Stock Vesting Issuer N 361 11/15/2022 Compensation Common 12/15/2022 Restricted Stock Vesting Issuer N 362 12/15/2022 Compensation Common 02/10/2023 Restricted Stock Vesting Issuer N 1421 02/10/2023 Compensation Common 02/14/2023 Restricted Stock Vesting Issuer N 2106 02/14/2023 Compensation Common 02/19/2023 Restricted Stock Vesting Issuer N 1682 02/19/2023 Compensation Common 02/25/2023 Restricted Stock Vesting Issuer N 3060 02/25/2023 Compensation Common 02/26/2023 Restricted Stock Vesting Issuer N 1844 02/26/2023 Compensation Common 05/01/2023 ESPP Purchase Issuer N 709 05/01/2023 Cash Y 08/21/2023 05/23/2023 /s/ Gerardo Ibarra-Munoz, as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for Jeffrey Elliott