X0508 4 2024-02-21 0 0001124140 EXACT SCIENCES CORP EXAS 0001689757 Elliott Jeffrey Thomas C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 Chief Financial Officer 1 Common Stock 2024-02-21 4 A 0 2711 0.00 A 6414 D Common Stock 2024-02-22 4 S 0 1351 59.78 D 5063 D Common Stock 1585 I Held in 401(k) Plan Represents shares of common stock received upon settlement of a performance share unit award on February 21, 2024. Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain performance stock units. In addition to the shares of Common Stock reported on this Form 4, which total 6,648 shares, Mr. Elliott also holds, in the aggregate, an additional 140,678 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. /s/ Jeffrey T. Elliott by Mark R. Busch, attorney-in-fact 2024-02-23