X0508 4 2023-08-21 0 0001124140 EXACT SCIENCES CORP EXAS 0001689757 Elliott Jeffrey Thomas C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 Chief Financial Officer 1 Common Stock 2022-05-02 5 A 0 E 260 47.41 A 29501 D Common Stock 2023-05-01 5 A 0 E 709 30.02 A 30210 D Common Stock 2023-08-21 4 S 0 30210 82.92 D 0 D Common Stock 1313 I Held in 401(k) Plan Represents shares of common stock purchased through Employee Stock Purchase Plan. The sale reported in this field was effected pursuant to a Rule 10b5-1 trading plan entered into on May 24, 2023 and previously disclosed in the Company's Quarterly Report on Form 10-Q for the quarter ended June 30, 2023. In addition to the shares of Common Stock reported on this Form 4, which total 1,313 shares, Mr. Elliott also holds, in the aggregate, an additional 147,763 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. /s/ Jeffrey T. Elliott by Mark R. Busch, attorney-in-fact 2023-08-23