X0306 4 2022-02-25 0 0001124140 EXACT SCIENCES CORP EXAS 0001689757 Elliott Jeffrey Thomas C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 Chief Financial Officer Common Stock 14716 D Common Stock 1190 I Held in 401(k) Plan Restricted Stock Units 2022-02-25 4 A 0 22802 0.00 A Common Stock 22802 22802 D In addition to the shares of Common Stock reported on this Form 4, which total 15,906 shares, Mr. Elliott also holds, in the aggregate, an additional 151,280 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vest in four equal annual installments beginning on the first anniversary of the grant date. /s/ Jeffrey T. Elliott by Mark R. Busch, attorney-in-fact 2022-03-01