X0306 4 2021-03-03 0 0001124140 EXACT SCIENCES CORP EXAS 0001689757 Elliott Jeffrey Thomas C/O EXACT SCIENCES CORP. 5505 ENDEAVOR LANE MADISON WI 53719 0 1 0 0 Chief Financial Officer Common Stock 2021-03-03 4 S 0 2632 135.02 D 38361 D Common Stock 1190 I Held in 401(k) Plan The sale reported in this field was effected pursuant to a Rule 10b5-1 trading plan. In addition to the shares of Common Stock reported on this Form 4, which total 39,551 shares, Mr. Elliott also holds, in the aggregate, an additional 135,562 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. /s/ Jeffrey T. Elliott by Mark R. Busch, attorney-in-fact 2021-03-05