X0306 4 2020-02-27 0 0001124140 EXACT SCIENCES CORP EXAS 0001689757 Elliott Jeffrey Thomas C/O EXACT SCIENCES CORP. 441 CHARMANY DRIVE MADISON WI 53719 0 1 0 0 Chief Financial Officer Common Stock 2020-02-27 4 M 0 5025 0.00 A 61141 D Common Stock 2020-02-28 4 S 0 2383 80.17 D 58578 D Common Stock 1147 I Held in 401(k) Plan Restricted Stock Units 2020-02-27 4 M 0 5025 0.00 D Common Stock 5025 10050 D Represents shares of common stock received upon vesting of a restricted stock unit award. Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain restricted stock units on February 27, 2020. In addition to the shares of Common Stock reported on this Form 4, which total 59,905 shares, Mr. Elliott also holds, in the aggregate, an additional 170,235 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Each restricted stock unit represents a contingent right to receive one share of common stock. Represents a restricted stock unit award granted on February 27, 2018 that partially vested on February 27, 2020. The restricted stock units vest in four equal annual installments beginning on February 27, 2019. /s/ Jeffrey T. Elliott by Mark Busch, attorney-in-fact 2020-03-02