X0306 4 2019-07-29 0 0001124140 EXACT SCIENCES CORP EXAS 0001689757 Elliott Jeffrey Thomas C/O EXACT SCIENCES CORP. 441 CHARMANY DRIVE MADISON WI 53719 0 1 0 0 Chief Financial Officer Common Stock 2019-04-30 5 A 0 E 368 60.60 A 41012 D Common Stock 2019-07-29 4 M 0 18750 0.00 A 59762 D Common Stock 2019-07-30 4 S 0 9845 105.60 D 49917 D Common Stock 960 I Held in 401(K) Plan Restricted Stock Units 2019-07-29 4 M 0 18750 0.00 D Common Stock 18750 18750 D Represents shares of common stock purchased through Employee Stock Purchase Plan. Represents shares of common stock received upon vesting of a restricted stock unit award, which were released on July 29, 2019. Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain restricted stock units, which were released on July 29, 2019. In addition to the shares of Common Stock reported on this Form 4, which total 50,877 shares, Mr. Elliott also holds, in the aggregate, an additional 159,233 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. Each restricted stock unit represents a contingent right to receive one share of common stock. Represents a restricted stock unit award granted on July 28, 2016 that partially vested on July 29, 2019. The restricted stock units vest in four equal annual installments beginning on July 28, 2017. /s/ Jeffrey T. Elliott by Mark R. Busch, attorney-in-fact 2019-07-31