X0306 4 2019-02-26 0 0001124140 EXACT SCIENCES CORP EXAS 0001689757 Elliott Jeffrey Thomas C/O EXACT SCIENCES CORP. 441 CHARMANY DRIVE MADISON WI 53719 0 1 0 0 Chief Financial Officer Common Stock 2019-02-27 4 M 0 5025 0.00 A 43091 D Common Stock 960 I Held in 401(K) Plan Stock Option (right to buy) 92.62 2019-02-26 4 A 0 11361 0.00 A 2020-02-26 2029-02-26 Common Stock 11361 11361 D Restricted Stock Units 2019-02-26 4 A 0 13747 0.00 A Common Stock 13747 13747 D Restricted Stock Units 2019-02-27 4 M 0 5025 0.00 D Common Stock 5025 15075 D Represents shares of common stock received upon vesting of a restricted stock unit award on February 27, 2019. In addition to the shares of Common Stock reported on this Form 4, which total 44,051 shares, Mr. Elliott also holds, in the aggregate, an additional 177,983 vested and unvested options to purchase shares of Common Stock and restricted stock units, with each restricted stock unit representing a contingent right to receive one share of Common Stock. These options vest and become exercisable in four equal annual installments beginning on the first anniversary of the grant date. Each restricted stock unit represents a contingent right to receive one share of common stock. These restricted stock units vest in four equal annual installments beginning on the first anniversary of the grant date. Represents a restricted stock unit award granted on February 27, 2018 that partially vested on February 27, 2019. The restricted stock units vest in four equal annual installments beginning on February 27, 2019. /s/ Jeffrey T. Elliott by Mark R. Busch, attorney-in-fact 2019-02-28