X0306 4 2017-07-28 0 0001124140 EXACT SCIENCES CORP EXAS 0001689757 Elliott Jeffrey Thomas C/O EXACT SCIENCES CORP. 441 CHARMANY DRIVE MADISON WI 53719 0 1 0 0 Chief Financial Officer Common Stock 2017-07-28 4 M 0 18750 0.00 A 19861 D Common Stock 2017-07-31 4 S 0 5846 39.41 D 14015 D Common Stock 472 I Held in 401(K) Account Restricted Stock Units 2017-07-28 4 M 0 18750 0.00 D Common Stock 18750 56250 D Represents shares of common stock received upon vesting of a restricted stock unit award. Represents shares sold pursuant to a Sell-to-Cover Rule 10b5-1 Plan to pay withholding taxes due in connection with the vesting of certain restricted stock units on July 28, 2017. Each restricted stock unit represents a contingent right to receive one share of common stock. Represents a restricted stock unit award granted on July 28, 2016 that partially vested on July 28, 2017. The restricted stock units vest in four equal annual installments beginning on July 28, 2017. /s/ Jeffrey T. Elliott by Mark R. Busch, attorney-in-fact 2017-08-01