X0306 4 2021-03-01 0 0001689657 Berkeley Lights, Inc. BLI 0001817415 Hobbs Eric 5858 HORTON STREET, SUITE 320 EMERYVILLE CA 94608 1 1 0 0 Chief Executive Officer Common Stock 2021-03-01 4 M 0 123967 2.54 A 123967 D Common Stock 2021-03-01 4 M 0 80000 2.10 A 203967 D Common Stock 2021-03-01 4 S 0 2300 57.6048 D 201667 D Common Stock 2021-03-01 4 S 0 4024 58.9656 D 197643 D Common Stock 2021-03-01 4 S 0 12666 59.9913 D 184977 D Common Stock 2021-03-01 4 S 0 60986 60.8593 D 123991 D Common Stock 2021-03-01 4 S 0 106781 61.7817 D 17210 D Common Stock 2021-03-01 4 S 0 17210 62.3826 D 0 D Stock Option 2.54 2021-03-01 4 M 0 123967 0.00 D 2027-04-13 Common Stock 123967 126033 D Stock Option 2.10 2021-03-01 4 M 0 80000 0.00 D 2027-11-01 Common Stock 80000 420000 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $57.18 to $57.95. The reporting person undertakes to provide Berkeley Lights, Inc. (the "Company"), any security holder of the Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $58.23 to $59.21. The reporting person undertakes to provide the Company, any security holder of the Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $59.24 to $60.23. The reporting person undertakes to provide the Company, any security holder of the Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $60.24 to $61.23. The reporting person undertakes to provide the Company, any security holder of the Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $61.24 to $62.23. The reporting person undertakes to provide the Company, any security holder of the Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The price reported in Column 4 is a weighted-average price. These shares were sold in multiple transactions at prices ranging from $62.24 to $62.80. The reporting person undertakes to provide the Company, any security holder of the Company, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the range set forth in this footnote. The stock option is partially vested and will vest with respect to the remaining shares in equal monthly installments of 5,208 shares until fully vested on April 14, 2021. The stock option is partially vested and will vest with respect to the remaining shares in equal monthly installments of 10,416 shares until fully vested on November 2, 2021. /s/ Stuart L. Merkadeau, Attorney-in-fact 2021-03-03