X0306 4 2017-06-30 0 0001680378 SenesTech, Inc. SNES 0001689608 Mayer Loretta Powers 3140 N. CADEN COURT, #1 FLAGSTAFF AZ 86004 1 1 0 0 CEO & Chief Scientific Officer Common Stock 2017-06-30 4 M 0 73333 A 431710 D Common Stock 2017-06-30 4 F 0 23052 5.94 D 408658 D Common Stock 100000 I 2016 Dyer Mayer Family Delaware Trust Restricted Stock Units 2017-06-30 4 M 0 73333 0 D 2017-06-30 2020-06-30 Common Stock 73333 146667 D These shares of Common Stock were acquired upon settlement of restricted stock units ("RSUs") granted to the reporting person on June 30, 2016. The RSUs vest over a three-year period, with one-third of the units vesting on June 30, 2017 and the remaining units vesting in equal quarterly tranches over the following twenty-four months of continuous service. On June 30, 2017, the RSUs partially settled for 50,281 shares of Common Stock, the amount of which was calculated by (a) 73,333 shares of Common Stock, the total number of shares of common stock subject to the RSUs that have vested as of June 30, 2017, less (b) 23,052 shares of Common Stock, which is the number of shares of Common Stock necessary for tax payments to be made on the reporting person's behalf per the terms of the agreement governing the RSUs. This transaction represents the settlement of RSUs as described in Footnote 1. One-third of the RSUs vested on June 30, 2017 and was settled for 50,281 shares of Common Stock. /s/ Loretta Powers Mayer 2017-07-05