<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0206</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2020-10-15</periodOfReport>

    <noSecuritiesOwned>1</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001689548</issuerCik>
        <issuerName>Praxis Precision Medicines, Inc.</issuerName>
        <issuerTradingSymbol>PRAX</issuerTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001252522</rptOwnerCik>
            <rptOwnerName>GALAKATOS NICHOLAS</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerStreet1>C/O PRAXIS PRECISION MEDICINES, INC.</rptOwnerStreet1>
            <rptOwnerStreet2>ONE BROADWAY, 16TH FLOOR</rptOwnerStreet2>
            <rptOwnerCity>CAMBRIDGE</rptOwnerCity>
            <rptOwnerState>MA</rptOwnerState>
            <rptOwnerZipCode>02142</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>1</isDirector>
            <isOfficer>0</isOfficer>
            <isTenPercentOwner>0</isTenPercentOwner>
            <isOther>0</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <footnotes></footnotes>

    <remarks>The Reporting Person, an employee of The Blackstone Group Inc. (&quot;Blackstone&quot;) or one of its affiliates, is a member of the board of directors of the issuer.  Certain affiliates of Blackstone have filed a separate Form 3 reporting securities of the issuer that they may be deemed to beneficially own.  The Reporting Person disclaims beneficial ownership of any securities of the issuer that may be deemed to be beneficially owned by affiliates of Blackstone.

Exhibit 24 - Power of Attorney</remarks>

    <ownerSignature>
        <signatureName>/s/ Alex Nemiroff, as Attorney-in-Fact</signatureName>
        <signatureDate>2020-10-15</signatureDate>
    </ownerSignature>
</ownershipDocument>
