X0206 3 2020-10-15 0 0001689548 Praxis Precision Medicines, Inc. PRAX 0001827759 Chaffee Stuart C/O PRAXIS PRECISION MEDICINES, INC. ONE BROADWAY, 16TH FLOOR CAMBRIDGE MA 02142 0 1 0 0 Chief Financial Officer Stock Option (Right to Buy) 2.27 2028-10-18 Common Stock 174554 D Stock Option (Right to Buy) 5.59 2030-06-04 Common Stock 65892 D Stock Option (Right to Buy) 8.91 2030-09-13 Common Stock 93457 D The shares underlying this stock option vest over a four-year period, with 25% having vested on the first anniversary of the vesting commencement date of November 20, 2017 and the remaining 75% vesting in 36 equal monthly installments following such first anniversary, subject to the reporting person's continued employment through each vesting date. The shares underlying this stock option shall vest over a four-year period, with 25% vesting on the 12-month anniversary of the vesting commencement date of May 28, 2020 and the remaining 75% vesting in 36 equal monthly installments following such first anniversary, subject to the reporting person's continued employment through each vesting date. The shares underlying this stock option shall vest over a four-year period, with 25% vesting on the 12-month anniversary of the vesting commencement date of September 8, 2020 and the remaining 75% vesting in 36 equal monthly installments following such first anniversary, subject to the reporting person's continued employment through each vesting date. Exhibit 24 - Power of Attorney /s/ Alex Nemiroff, as Attorney-in-Fact 2020-10-15