X0206 3 2020-10-15 0 0001689548 Praxis Precision Medicines, Inc. PRAX 0001217420 YOUNG WILLIAM D C/O PRAXIS PRECISION MEDICINES, INC. ONE BROADWAY, 16TH FLOOR CAMBRIDGE MA 02142 1 0 0 0 Stock Options (Right to Buy) 0.11 2027-05-07 Common Stock 27980 D Stock Options (Right to Buy) 5.59 2030-06-04 Common Stock 8754 D Stock Options (Right to Buy) 8.91 2030-09-13 Common Stock 65420 D The shares underlying this stock option vest over a four-year period, with 25% having vested on the first anniversary of the vesting commencement date of December 12, 2016 and the remaining 75% vesting in 36 equal monthly installments following such first anniversary, subject to the reporting person's continued employment through each vesting date. The shares underlying this stock option shall vest over a four-year period, with 25% vesting on the 12-month anniversary of the vesting commencement date of May 28, 2020 and the remaining 75% vesting in 36 equal monthly installments following such first anniversary, subject to the reporting person's continued employment through each vesting date. The shares underlying this stock option shall vest over a four-year period, with 25% vesting on the 12-month anniversary of the vesting commencement date of September 8, 2020 and the remaining 75% vesting in 36 equal monthly installments following such first anniversary, subject to the reporting person's continued employment through each vesting date. The Reporting Person, a Senior Advisor of The Blackstone Group Inc. ("Blackstone") or one of its affiliates, is a member of the board of directors of the Issuer. Certain affiliates of Blackstone have filed a separate Form 3 reporting securities of the Issuer that they may be deemed to beneficially own. The Reporting Person disclaims beneficial ownership of any securities of the Issuer that may be deemed to be beneficially owned by affiliates of Blackstone. Exhibit 24 - Power of Attorney /s/ Alex Nemiroff, as Attorney-in-Fact 2020-10-15