Collaboration and License Agreements (Details) - USD ($) $ in Thousands	3 Months Ended				9 Months Ended
	Sep. 30, 2025	Mar. 31, 2025	Sep. 30, 2024	Mar. 31, 2024	Sep. 30, 2025	Sep. 30, 2024	Feb. 28, 2023
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaboration revenue	$ 1,614		$ 19,570		$ 24,122	$ 173,384
Vertex
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Strategic collaboration agreement, term							4 years
Collaboration revenue	1,600		19,600		24,100	172,400
Cumulative catch-up adjustment		$ 12,300		$ 142,800
Vertex | Collaboration service revenue
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaboration revenue	1,200		2,600		4,000	12,200
Vertex | Recognition of upfront and milestone payments
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Collaboration revenue	400		$ 17,000		20,100	$ 17,400
Vertex | License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue, remaining performance obligation, amount	$ 500				$ 500