CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY - USD ($) $ in Thousands	Total	Common Stock	Additional Paid‑in Capital	Accumulated Other Comprehensive Income (Loss)	Accumulated Deficit
Beginning balance (in shares) at Dec. 31, 2021		31,224,336
Beginning balance at Dec. 31, 2021	$ 298,718	$ 3	$ 392,384	$ 0	$ (93,669)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)		84,526
Issuance of common stock upon exercise of stock options	$ 195		195
Vesting of early exercised options (in shares)	53,741	58,015
Vesting of early exercised options	$ 135		135
Purchase of common stock under the employee stock purchase plan (in shares)		27,890
Purchase of common stock under the employee stock purchase plan	284		284
Stock‑based compensation	9,895		9,895
Other comprehensive income (loss)	(2,057)			(2,057)
Net loss	$ (94,616)				(94,616)
Ending balance (in shares) at Dec. 31, 2022	31,394,767	31,394,767
Ending balance at Dec. 31, 2022	$ 212,554	$ 3	402,893	(2,057)	(188,285)
Increase (Decrease) in Stockholders' Equity [Roll Forward]
Issuance of common stock upon exercise of stock options (in shares)	214,078	214,078
Issuance of common stock upon exercise of stock options	$ 1,187		1,187
Issuance of common stock in connection with the Vertex Agreement (in shares)		1,618,613
Issuance of common stock in connection with the Vertex Agreement	$ 19,407		19,407
Vesting of early exercised options (in shares)	14,745	33,416
Vesting of early exercised options	$ 91		91
Vesting of restricted stock units (in shares)		138,361
Purchase of common stock under the employee stock purchase plan (in shares)		38,061
Purchase of common stock under the employee stock purchase plan	443		443
Stock‑based compensation	13,111		13,111
Other comprehensive income (loss)	2,252			2,252
Net loss	$ (6,685)				(6,685)
Ending balance (in shares) at Dec. 31, 2023	33,437,296	33,437,296
Ending balance at Dec. 31, 2023	$ 242,360	$ 3	$ 437,132	$ 195	$ (194,970)