Collaboration and License Agreements - Narrative (Details) - USD ($) $ in Millions	1 Months Ended		3 Months Ended	9 Months Ended
	Oct. 31, 2023	Feb. 28, 2023	Sep. 30, 2023	Sep. 30, 2023
Vertex
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Strategic collaboration agreement, term		4 years
Cumulative catch-up adjustment			$ 21.3
Vertex | Subsequent Event
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Milestone payment	$ 17.5
Vertex | Private Placement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Net proceeds from issuance of common stock		$ 26.3
Number of shares purchases in equity investment (in shares)		1,618,613
Consideration amount		$ 485.0
Vertex | License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Up-front payment		223.7
Revenue, remaining performance obligation, amount		232.0	157.9	$ 157.9
Premium		$ 6.9
Pierrepont Therapeutics, Inc
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue recognized			$ 0.0	$ 0.0