Collaboration and License Agreements (Details) - USD ($) $ in Thousands	1 Months Ended	3 Months Ended
	Feb. 28, 2023	Mar. 31, 2023	Mar. 31, 2022
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Strategic collaboration agreement, term	4 years
Revenue from contract with customer		$ 25,260	$ 0
Vertex
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Revenue from contract with customer		4,900
Vertex | Private Placement
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Net proceeds from issuance of common stock	$ 26,300
Number of shares purchases in equity investment (in shares)	1,618,613
Vertex | License
Collaborative Arrangement and Arrangement Other than Collaborative [Line Items]
Up-front payment	$ 223,700
Premium	6,900
Consideration amount	485,000
Revenue, remaining performance obligation, amount	$ 232,000	211,600
Revenue from contract with customer		25,300
Agreement deferred revenue		$ 20,400