Exhibit 23.1

Consent of Independent Registered Public Accounting Firm

We consent to the reference to our firm under the caption “Experts” and to the use of our report dated August 6, 2021, in the Registration Statement (Form S-1) and related Prospectus of Entrada Therapeutics, Inc. dated October 8, 2021.

/s/ Ernst & Young LLP

Boston, Massachusetts

October 8, 2021