<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: JW Asset Management, LLC -->
          <cik>0001549738</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Common Shares, No Par Value</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>06/30/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001688757</issuerCik>
        <issuerName>Establishment Labs Holdings, Inc.</issuerName>
        <issuerCusips>
          <issuerCusipNumber>G31249108</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>11401 Century Oaks Terrace</com:street1>
          <com:street2>Suite 400</com:street2>
          <com:city>Austin</com:city>
          <com:stateOrCountry>TX</com:stateOrCountry>
          <com:zipCode>78758</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>JW Asset Management, LLC</reportingPersonName>
      <memberGroup>a</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>2692856.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>2692856.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2692856.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>9.15</classPercent>
      <typeOfReportingPerson>IA</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>JW Partners, LP</reportingPersonName>
      <memberGroup>a</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>2006252.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>2006252.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2006252.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>6.82</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>JW Opportunities Fund, LLC</reportingPersonName>
      <memberGroup>a</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>686604.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>686604.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>686604.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>2.33</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>JW GP, LLC</reportingPersonName>
      <memberGroup>a</memberGroup>
      <citizenshipOrOrganization>DE</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>2692856.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>2692856.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2692856.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>9.15</classPercent>
      <typeOfReportingPerson>PN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Jason G. Wild</reportingPersonName>
      <memberGroup>a</memberGroup>
      <citizenshipOrOrganization>X1</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>0.00</soleVotingPower>
        <sharedVotingPower>2692856.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>2692856.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>2692856.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>9.15</classPercent>
      <typeOfReportingPerson>IN</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>Establishment Labs Holdings, Inc.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>11401 Century Oaks Terrace, Suite 400 Austin TX 78758</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>JW Asset Management, LLC</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>1051 N. Venetian Blvd Miami Beach 33139</principalBusinessOfficeOrResidenceAddress>
        <citizenship>USA</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>IA</typeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>The Information required by Items 4(a)  -  (c) is set forth in Rows 5-12 of the cover page for each Reporting Person hereto and is incorporated by reference for each Reporting Person.  The percentage ownership of the Reporting Persons is based on the 29,430,390 outstanding shares of Common Stock of the Issuer, as of May 7, 2026, as disclosed on the Issuer's 10-Q filed with the SEC on May 8, 2026.</amountBeneficiallyOwned>
        <classPercent>The Information required by Items 4(a)  -  (c) is set forth in Rows 5-12 of the cover page for each Reporting Person hereto and is incorporated by reference for each Reporting Person.  The percentage ownership of the Reporting Persons is based on the 29,430,390 outstanding shares of Common Stock of the Issuer, as of May 7, 2026, as disclosed on the Issuer's 10-Q filed with the SEC on May 8, 2026.</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>The Information required by Items 4(a)  -  (c) is set forth in Rows 5-12 of the cover page for each Reporting Person hereto and is incorporated by reference for each Reporting Person.  The percentage ownership of the Reporting Persons is based on the 29,430,390 outstanding shares of Common Stock of the Issuer, as of May 7, 2026, as disclosed on the Issuer's 10-Q filed with the SEC on May 8, 2026.</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>The Information required by Items 4(a)  -  (c) is set forth in Rows 5-12 of the cover page for each Reporting Person hereto and is incorporated by reference for each Reporting Person.  The percentage ownership of the Reporting Persons is based on the 29,430,390 outstanding shares of Common Stock of the Issuer, as of May 7, 2026, as disclosed on the Issuer's 10-Q filed with the SEC on May 8, 2026.</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>The Information required by Items 4(a)  -  (c) is set forth in Rows 5-12 of the cover page for each Reporting Person hereto and is incorporated by reference for each Reporting Person.  The percentage ownership of the Reporting Persons is based on the 29,430,390 outstanding shares of Common Stock of the Issuer, as of May 7, 2026, as disclosed on the Issuer's 10-Q filed with the SEC on May 8, 2026.</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>The Information required by Items 4(a)  -  (c) is set forth in Rows 5-12 of the cover page for each Reporting Person hereto and is incorporated by reference for each Reporting Person.  The percentage ownership of the Reporting Persons is based on the 29,430,390 outstanding shares of Common Stock of the Issuer, as of May 7, 2026, as disclosed on the Issuer's 10-Q filed with the SEC on May 8, 2026.</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>Y</notApplicableFlag>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>JW Asset Management, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Jason Klarreich</signature>
        <title>Jason Klarreich/Attorney-In-Fact</title>
        <date>07/31/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>JW Partners, LP</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Jason Klarreich</signature>
        <title>Jason Klarreich/Attorney-In-Fact</title>
        <date>07/31/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>JW Opportunities Fund, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Jason Klarreich</signature>
        <title>Jason Klarreich/Attorney-In-Fact</title>
        <date>07/31/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>JW GP, LLC</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Jason Klarreich</signature>
        <title>Jason Klarreich/Attorney-In-Fact</title>
        <date>07/31/2026</date>
      </signatureDetails>
    </signatureInformation>
    <signatureInformation>
      <reportingPersonName>Jason G. Wild</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Jason Klarreich</signature>
        <title>Jason Klarreich/Attorney-In-Fact</title>
        <date>07/31/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
