X0306 4 2017-12-04 0 0001505512 Regulus Therapeutics Inc. RGLS 0001686178 WRIGHT TIMOTHY MICHAEL C/O REGULUS THERAPEUTICS INC. 10614 SCIENCE CENTER DRIVE SAN DIEGO CA 92121 0 1 0 0 Chief R & D Officer Stock Option (Right to Buy) 3.30 2017-12-04 4 A 0 100000 0.00 A 2017-12-04 2026-10-02 Common Stock 100000 100000 D On October 3, 2016, the reporting person was granted an option to purchase 400,000 shares of common stock. The option vests in increments of 100,000 shares upon the achievement of certain performance criteria. On December 4, 2017, the performance criteria for the first goal were met, resulting in the vesting of 100,000 shares. Christopher Aker, Attorney in Fact 2017-12-05