<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:xsd="http://www.w3.org/2001/XMLSchema" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance">
<headerData>
<submissionType>144</submissionType>
<filerInfo>
<filer>
<filerCredentials>
<cik>0001685994</cik>
<ccc>XXXXXXXX</ccc>
</filerCredentials>
</filer>
<liveTestFlag>LIVE</liveTestFlag>
</filerInfo>
</headerData>
<formData>
<issuerInfo>
<issuerCik>0001707502</issuerCik>
<issuerName>Solid Biosciences Inc.</issuerName>
<secFileNumber>001-38360</secFileNumber>
<issuerAddress>
<street1 xmlns="http://www.sec.gov/edgar/common">500 Rutherford Avenue</street1>
<city xmlns="http://www.sec.gov/edgar/common">Charlestown</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">MA</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">02129</zipCode>
</issuerAddress>
<issuerContactPhone>(617)-337-4680</issuerContactPhone>
<nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Cumbo Alexander</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
<relationshipsToIssuer>
<relationshipToIssuer>Officer</relationshipToIssuer>
<relationshipToIssuer>Director</relationshipToIssuer>
</relationshipsToIssuer>
</issuerInfo>
<securitiesInformation>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<brokerOrMarketmakerDetails>
<name>ETRADE FINANCIAL CORPORATION</name>
<address>
<street1 xmlns="http://www.sec.gov/edgar/common">3 EDISON DRIVE</street1>
<city xmlns="http://www.sec.gov/edgar/common">ALPHARETTA</city>
<stateOrCountry xmlns="http://www.sec.gov/edgar/common">GA</stateOrCountry>
<zipCode xmlns="http://www.sec.gov/edgar/common">30005</zipCode>
</address>
</brokerOrMarketmakerDetails>
<noOfUnitsSold>10808</noOfUnitsSold>
<aggregateMarketValue>55228.88</aggregateMarketValue>
<noOfUnitsOutstanding>77996546</noOfUnitsOutstanding>
<approxSaleDate>12/03/2025</approxSaleDate>
<securitiesExchangeName>NASDAQ</securitiesExchangeName>
</securitiesInformation>
<securitiesToBeSold>
<securitiesClassTitle>Common Stock</securitiesClassTitle>
<acquiredDate>12/02/2025</acquiredDate>
<natureOfAcquisitionTransaction>Settlement of vested restricted stock units</natureOfAcquisitionTransaction>
<nameOfPersonfromWhomAcquired>Issuer</nameOfPersonfromWhomAcquired>
<isGiftTransaction>N</isGiftTransaction>
<amountOfSecuritiesAcquired>10808</amountOfSecuritiesAcquired>
<paymentDate>12/02/2025</paymentDate>
<natureOfPayment>Compensation</natureOfPayment>
</securitiesToBeSold>
<nothingToReportFlagOnSecuritiesSoldInPast3Months>Y</nothingToReportFlagOnSecuritiesSoldInPast3Months>
<remarks>The sale reported on this Form 144 was made to cover witholding taxes following the vesting of previously granted restricted stock units pursuant to a durable sale instruction letter adopted by Mr. Cumbo on August 18, 2024 effecting the sell-cover-election. The sale does not represent a discretionary trade by Mr. Cumbo.</remarks>
<noticeSignature>
<noticeDate>12/03/2025</noticeDate>
<planAdoptionDates>
<planAdoptionDate>08/18/2024</planAdoptionDate>
</planAdoptionDates>
<signature>/s/ Kimberly Cornwell as attorney-in-fact for Alexander Cumbo</signature>
</noticeSignature>
</formData>
</edgarSubmission>
