X0508 4 2023-07-28 0 0001358762 REATA PHARMACEUTICALS INC RETA 0001685986 Ruff Shamim 5320 LEGACY DRIVE PLANO TX 75024 1 0 0 0 1 Class A common stock 2023-07-28 4 M 0 1250 92.20 A 8609 D Class A common stock 2023-07-28 4 M 0 6666 92.20 A 15275 D Class A common stock 2023-07-28 4 M 0 319 92.20 A 15594 D Class A common stock 2023-07-28 4 S 0 8235 164.5279 D 7359 D Stock Option (right to buy) 92.20 2023-07-28 4 M 0 1250 0.00 D 2031-04-15 Class A common stock 1250 0 D Stock Option (right to buy) 92.20 2023-07-28 4 M 0 6666 0.00 D 2031-04-15 Class A common stock 6666 3334 D Stock Option (right to buy) 92.20 2023-07-28 4 M 0 319 0.00 D 2031-04-15 Class A common stock 319 0 D The exercise and sale reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person on March 14, 2023. The price reported in Column 4 is a weighted average price. These shares were sold in multiple transactions on one day at prices ranging from $164.25 to $164.69. The reporting person undertakes to provide to the issuer, any security holder of the issuer, or the staff of the Securities and Exchange Commission, upon request, full information regarding the number of shares sold at each separate price within the ranges set forth in this footnote. The options vested on July 15, 2021. The options vest in three equal yearly installments through April 15, 2024, subject to continued service through each vesting date. The options vested on July 15, 2021. /s/ Tracy Herson, attorney-in-fact 2023-08-01