Exhibit 15.1

CONSENT OF INDEPENDENT REGISTERED PUBLIC ACCOUNTING FIRM

We hereby consent to the incorporation by reference in the Registration Statements on Form S-8 (No. 333-216170) and Form F-3, as amended (Nos. 333-222820 and 333-221462) of ObsEva SA of our report dated March 5, 2019, relating to the financial statements, which appears in this Form 20-F.

s/ PricewaterhouseCoopers SA

Geneva, Switzerland

March 5, 2019