<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/ownership" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>144</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <cik>0001982142</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <issuerInfo>
      <issuerCik>0001684693</issuerCik>
      <issuerName>Sol-Gel Technologies Ltd.</issuerName>
      <secFileNumber>001-38367</secFileNumber>
      <issuerAddress>
        <com:street1>7 GOLDA MEIR ST.</com:street1>
        <com:street2>WEIZMANN SCIENCE PARK</com:street2>
        <com:city>NESS ZIONA</com:city>
        <com:stateOrCountry>L3</com:stateOrCountry>
        <com:zipCode>7403648</com:zipCode>
      </issuerAddress>
      <issuerContactPhone>97289313433</issuerContactPhone>
      <nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>Seri Levy Alon</nameOfPersonForWhoseAccountTheSecuritiesAreToBeSold>
      <relationshipsToIssuer>
        <relationshipToIssuer>Officer</relationshipToIssuer>
      </relationshipsToIssuer>
    </issuerInfo>
    <securitiesInformation>
      <securitiesClassTitle>Ordinary</securitiesClassTitle>
      <brokerOrMarketmakerDetails>
        <name>Oppenheimer &amp; Co. Inc.</name>
        <address>
          <com:street1>85 Broad St.</com:street1>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10004</com:zipCode>
        </address>
      </brokerOrMarketmakerDetails>
      <noOfUnitsSold>55389</noOfUnitsSold>
      <aggregateMarketValue>169490.34</aggregateMarketValue>
      <noOfUnitsOutstanding>23129469</noOfUnitsOutstanding>
      <approxSaleDate>06/27/2023</approxSaleDate>
      <securitiesExchangeName>NASDAQ</securitiesExchangeName>
    </securitiesInformation>
    <securitiesToBeSold>
      <securitiesClassTitle>Ordinary</securitiesClassTitle>
      <acquiredDate>03/29/2015</acquiredDate>
      <natureOfAcquisitionTransaction>Employee Stock Option Plan</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>From the Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>132848</amountOfSecuritiesAcquired>
      <paymentDate>06/27/2023</paymentDate>
      <natureOfPayment>Cash, Upon Exercise, Same Day Sale</natureOfPayment>
    </securitiesToBeSold>
    <securitiesToBeSold>
      <securitiesClassTitle>Ordinary</securitiesClassTitle>
      <acquiredDate>02/08/2016</acquiredDate>
      <natureOfAcquisitionTransaction>Employee Stock Option Plan</natureOfAcquisitionTransaction>
      <nameOfPersonfromWhomAcquired>From the Issuer</nameOfPersonfromWhomAcquired>
      <isGiftTransaction>N</isGiftTransaction>
      <amountOfSecuritiesAcquired>19014</amountOfSecuritiesAcquired>
      <paymentDate>06/27/2023</paymentDate>
      <natureOfPayment>Cash, Upon Exercise, Same Day Sale</natureOfPayment>
    </securitiesToBeSold>
    <nothingToReportFlagOnSecuritiesSoldInPast3Months>N</nothingToReportFlagOnSecuritiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Alon Seri- Levy</name>
        <address>
          <com:street1>7 Golda Meir St.</com:street1>
          <com:street2>Weizmann Science Park</com:street2>
          <com:city>Ness Ziona</com:city>
          <com:stateOrCountry>L3</com:stateOrCountry>
          <com:zipCode>7403650</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Ordinary</securitiesClassTitle>
      <saleDate>03/27/2023</saleDate>
      <amountOfSecuritiesSold>6779</amountOfSecuritiesSold>
      <grossProceeds>27436.19</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Alon Seri- Levy</name>
        <address>
          <com:street1>7 Golda Meir St.</com:street1>
          <com:street2>Weizmann Science Park</com:street2>
          <com:city>Ness Ziona</com:city>
          <com:stateOrCountry>L3</com:stateOrCountry>
          <com:zipCode>7403650</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Ordinary</securitiesClassTitle>
      <saleDate>04/03/2023</saleDate>
      <amountOfSecuritiesSold>18368</amountOfSecuritiesSold>
      <grossProceeds>69869.39</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Alon Seri- Levy</name>
        <address>
          <com:street1>7 Golda Meir St.,</com:street1>
          <com:street2>Weizmann Science Park</com:street2>
          <com:city>Ness Ziona</com:city>
          <com:stateOrCountry>L3</com:stateOrCountry>
          <com:zipCode>7403650</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Ordinary</securitiesClassTitle>
      <saleDate>05/01/2023</saleDate>
      <amountOfSecuritiesSold>37149</amountOfSecuritiesSold>
      <grossProceeds>127568.36</grossProceeds>
    </securitiesSoldInPast3Months>
    <securitiesSoldInPast3Months>
      <sellerDetails>
        <name>Alon Seri- Levy</name>
        <address>
          <com:street1>7 Golda Meir St.,</com:street1>
          <com:street2>Weizmann Science Park</com:street2>
          <com:city>Ness Ziona</com:city>
          <com:stateOrCountry>L3</com:stateOrCountry>
          <com:zipCode>7403650</com:zipCode>
        </address>
      </sellerDetails>
      <securitiesClassTitle>Ordinary</securitiesClassTitle>
      <saleDate>06/01/2023</saleDate>
      <amountOfSecuritiesSold>34177</amountOfSecuritiesSold>
      <grossProceeds>111494.87</grossProceeds>
    </securitiesSoldInPast3Months>
    <remarks>To be sold under a 10b5-1 sale plan adopted on 02/23/2023</remarks>
    <noticeSignature>
      <noticeDate>06/27/2023</noticeDate>
      <planAdoptionDates>
        <planAdoptionDate>02/23/2023</planAdoptionDate>
      </planAdoptionDates>
      <signature>Alon Seri- Levy</signature>
    </noticeSignature>
  </formData>
</edgarSubmission>
