X0306 4 2022-06-30 0 0001683553 SPRUCE BIOSCIENCES, INC. SPRB 0001533302 Gharib Samir M. 2001 JUNIPERO SERRA BOULEVARD, SUITE 640 DALY CITY CA 94014 0 1 0 0 President & CFO Common Stock 2022-06-30 4 M 0 37500 A 41132 D Common Stock 2022-06-30 5 A 0 E 5446 1.479 A 46578 D Common Stock 2022-06-30 4 F 0 12968 1.74 D 33610 D Restricted Stock Units 2022-06-30 4 M 0 37500 0.00 D Common Stock 37500 262500 D Each restricted stock unit ("RSU") represents a contingent right to receive one share of SPRB common stock. Shares acquired by the Reporting Person pursuant to the Issuer's 2020 Employee Stock Purchase Plan in a transaction that was exempt under both Rule 16b-3(d) and Rule 16b-3(c). The Reporting Person acquired the maximum shares allowable pursuant to Section 423 of the Internal Revenue Code. Represents shares withheld by the Issuer to satisfy a tax obligation realized by the Reporting Person upon the vesting and settlement of RSUs. On December 16, 2021, the Reporting Person was granted 150,000 time-based RSUs. 25% of the RSUs vested on June 30, 2022, 25% shall vest on December 31, 2022 and 50% shall vest on June 30, 2023, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). The Reporting Person was also granted 150,000 performance-based RSUs, which shall vest upon the achievement of specified performance goals. Represents the aggregate balances of 112,500 time-based RSUs and 150,000 performance-based RSUs. /s/ Samir M. Gharib 2022-07-05