X0306 4 2022-05-25 0 0001683553 SPRUCE BIOSCIENCES, INC. SPRB 0001669220 Aynechi Tiba C/O SPRUCE BIOSCIENCES, INC. 2001 JUNIPERO SERRA BOULEVARD, SUITE 640 DALY CITY CA 94014 1 0 0 0 Stock Option (Right to Buy) 1.32 2022-05-25 4 A 0 22500 0.00 A 2032-05-24 Common Stock 22500 22500 D The shares vest on the first anniversary of the Grant Date, provided that the Option will in any case be fully vested on the date of Company's 2023 annual stockholder meeting, subject to the Reporting Person's Continuous Service (as defined in the 2020 Equity Incentive Plan (the "Plan")) through such vesting date and will vest in full upon a Change in Control (as defined in the Plan). /s/ Samir Gharib, Attorney-in-Fact 2022-05-27