X0206 3 2022-01-01 0 0001683553 SPRUCE BIOSCIENCES, INC. SPRB 0001903669 Szwarcberg Javier B. 2001 JUNIPERO SERRA BOULEVARD, SUITE 640 DALY CITY CA 94014 1 1 0 0 Chief Executive Officer Employee Stock Option (right to buy) 4.59 2032-01-03 Common Stock 750000 D Employee Stock Option (right to buy) 4.59 2032-01-03 Common Stock 250000 D The shares subject to the stock option vest over a four-year period commencing January 3, 2022, with 1/4th of the shares vesting on January 3, 2023 and 1/36th of the remaining shares vesting on a monthly basis, subject to Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). The option was granted on January 3, 2022. The shares vest upon the achievement of specified performance goals, subject to the Reporting Person's Continuous Service (as defined in the Issuer's 2020 Equity Incentive Plan). The option was granted on January 3, 2022. /s/ Javier B. Szwarcberg 2022-01-10