Summary of Significant Accounting Policies - Property and Equipment and Software Capitalization (Details) - USD ($)	12 Months Ended
	Dec. 31, 2019	Jan. 01, 2019	Dec. 31, 2018
Property, Plant and Equipment [Line Items]
Property and equipment, net		$ 209,494,000	$ 211,977,000
Laboratory equipment
Property, Plant and Equipment [Line Items]
Estimated Useful Life	5 years
Computer equipment and software
Property, Plant and Equipment [Line Items]
Estimated Useful Life	3 years
Other assets including automobiles, furniture and fixtures
Property, Plant and Equipment [Line Items]
Estimated Useful Life	5 years
Capitalized software
Property, Plant and Equipment [Line Items]
Property and equipment, net			$ 0