X0306 4 2022-05-18 0 0001682852 Moderna, Inc. MRNA 0001222012 AFEYAN NOUBAR C/O FLAGSHIP PIONEERING, INC. 55 CAMBRIDGE PARKWAY, SUITE 800E CAMBRIDGE MA 02142 1 0 0 0 Common Stock 2022-05-18 4 S 0 10000 138.38 D 2567209 D Common Stock 12882819 I By Flagship Ventures Fund IV, L.P. and Flagship Ventures Fund IV-Rx, L.P. Common Stock 3924 I By Flagship Pioneering, Inc. These sales were effected by the reporting person pursuant to a Rule 10b5-1 trading plan adopted on September 15, 2021, as amended on March 11, 2022. Includes shares received in prior distributions-in-kind from Flagship VentureLabs IV LLC ("VentureLabs IV"), Flagship Ventures Fund IV, L.P. ("Flagship Fund IV"), Flagship Fund Ventures Fund IV-Rx, L.P. ("Flagship Fund IV-Rx") and Flagship Fund IV General Partner LLC ("Flagship Fund IV GP") made in accordance with the exemptions afforded by Rule 16a-13 and Rule 16a-9 of the Securities Exchange Act of 1934, as amended. 10,801,059 shares are held directly by Flagship Fund IV (which reflects prior distributions-in-kind from VentureLabs IV) and 2,081,760 shares are held directly by Flagship Fund IV-Rx. Flagship Fund IV GP is the general partner of each of Flagship Fund IV and Flagship Fund IV-Rx. The reporting person is the sole manager of Flagship Fund IV GP and disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein. 3,924 shares are held directly by Flagship Pioneering, Inc. ("Flagship Pioneering"). The reporting person is the CEO and sole stockholder of Flagship Pioneering and disclaims beneficial ownership of such shares except to the extent of his pecuniary interest therein. Noubar B. Afeyan, Ph.D. By: /s/ Noubar B. Afeyan, Ph.D. 2022-05-20