144 0001563422 XXXXXXXX LIVE 0001682639 HYPERION DEFI, INC. 001-38365 23461 SOUTH POINTE DRIVE, SUITE 390 LAGUNA HILLS CA 92653 833-393-6684 MATHER CHARLES E IV Director Common Fidelity Brokerage Services LLC

245 Summer Street Boston MA 02110

1362 17515.00 2882808 07/22/2025 NASDAQ Common 09/18/2018 Open Mkt Purchase Public Market N 12 09/18/2018 Open market Common 09/19/2018 Open Mkt Purchase Public Market N 37 09/19/2018 Public Market Common 05/28/2021 Open Mkt Purchase Public Market N 37 05/28/2021 Open market Common 11/01/2021 Open Mkt Purchase Public Market N 49 11/01/2021 Open Market Common 03/31/2022 Open Mkt Purchase Public Market N 49 03/31/2022 Open Market Common 05/18/2022 Open Mkt Purchase Public Marekt N 87 05/18/2022 Open Market Common 05/15/2023 Open Mkt Purchase Public Market N 49 05/15/2023 Open Market Common 05/26/2023 Open Mkt Purchase Public Market N 37 05/26/2023 Open market Common 06/17/2025 Stock Award Issuer N 1000 06/17/2025 Compensation Y 07/22/2025 /s/ Heather Foxworth as a duly authorized representative of Fidelity Brokerage Services LLC, as attorney-in-fact for MATHER CHARLES E IV