<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13g" xmlns:com="http://www.sec.gov/edgar/common">
  <schemaVersion>X0202</schemaVersion>
<headerData>
    <submissionType>SCHEDULE 13G/A</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Forsakringsaktiebolaget Avanza Pension -->
          <cik>0001540910</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>



    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <amendmentNo>4</amendmentNo>
      <securitiesClassTitle>COMMON STOCK, PAR VALUE $0.001 PER SHARE</securitiesClassTitle>
      <eventDateRequiresFilingThisStatement>03/30/2026</eventDateRequiresFilingThisStatement>
      <issuerInfo>
        <issuerCik>0001682639</issuerCik>
        <issuerName>HYPERION DEFI, INC.</issuerName>
        <issuerCusips>
          <issuerCusipNumber>30234E203</issuerCusipNumber>
        </issuerCusips>
        <issuerPrincipalExecutiveOfficeAddress>
          <com:street1>295 Madison Avenue</com:street1>
          <com:street2>Suite 2400</com:street2>
          <com:city>New York</com:city>
          <com:stateOrCountry>NY</com:stateOrCountry>
          <com:zipCode>10017</com:zipCode>
        </issuerPrincipalExecutiveOfficeAddress>
      </issuerInfo>
      <designateRulesPursuantThisScheduleFiled>
        <designateRulePursuantThisScheduleFiled>Rule 13d-1(b)</designateRulePursuantThisScheduleFiled>
      </designateRulesPursuantThisScheduleFiled>
    </coverPageHeader>
    <coverPageHeaderReportingPersonDetails>


      <reportingPersonName>Forsakringsaktiebolaget Avanza Pension</reportingPersonName>
      <citizenshipOrOrganization>V7</citizenshipOrOrganization>
      <reportingPersonBeneficiallyOwnedNumberOfShares>
        <soleVotingPower>1125785.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>0.00</soleDispositivePower>
        <sharedDispositivePower>1125785.00</sharedDispositivePower>
      </reportingPersonBeneficiallyOwnedNumberOfShares>
      <reportingPersonBeneficiallyOwnedAggregateNumberOfShares>1125785.00</reportingPersonBeneficiallyOwnedAggregateNumberOfShares>
      <aggregateAmountExcludesCertainSharesFlag>N</aggregateAmountExcludesCertainSharesFlag>
      <classPercent>9.88</classPercent>
      <typeOfReportingPerson>IC</typeOfReportingPerson>
    </coverPageHeaderReportingPersonDetails>
    <items>
      <item1>
        <issuerName>HYPERION DEFI, INC.</issuerName>
        <issuerPrincipalExecutiveOfficeAddress>295 Madison Avenue, Suite 2400, New York NY, 10017</issuerPrincipalExecutiveOfficeAddress>
      </item1>
      <item2>
        <filingPersonName>Forsakringsaktiebolaget Avanza Pension</filingPersonName>
        <principalBusinessOfficeOrResidenceAddress>Box 1399
STOCKHOLM, 11139
SWEDEN</principalBusinessOfficeOrResidenceAddress>
        <citizenship>Forsakringsaktiebolaget Avanza Pension is a company organized under the laws of Sweden</citizenship>
      </item2>
      <item3>
        <notApplicableFlag>N</notApplicableFlag>
        <typeOfPersonFiling>FI</typeOfPersonFiling>
        <otherTypeOfPersonFiling>Insurance company</otherTypeOfPersonFiling>
      </item3>
      <item4>
        <amountBeneficiallyOwned>1,125,785</amountBeneficiallyOwned>
        <classPercent>9,88</classPercent>
        <numberOfSharesPersonHas>
          <solePowerOrDirectToVote>1,125,785</solePowerOrDirectToVote>
          <sharedPowerOrDirectToVote>None</sharedPowerOrDirectToVote>
          <solePowerOrDirectToDispose>None</solePowerOrDirectToDispose>
          <sharedPowerOrDirectToDispose>1,125,785</sharedPowerOrDirectToDispose>
        </numberOfSharesPersonHas>
      </item4>
      <item5>
        <notApplicableFlag>Y</notApplicableFlag>
      </item5>
      <item6>
        <notApplicableFlag>Y</notApplicableFlag>
      </item6>
      <item7>
        <notApplicableFlag>Y</notApplicableFlag>
      </item7>
      <item8>
        <notApplicableFlag>Y</notApplicableFlag>
      </item8>
      <item9>
        <notApplicableFlag>Y</notApplicableFlag>
      </item9>
      <item10>
        <notApplicableFlag>N</notApplicableFlag>
        <certifications>By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under ?? 240.14a-11.</certifications>
      </item10>
    </items>
    <signatureInformation>
      <reportingPersonName>Forsakringsaktiebolaget Avanza Pension</reportingPersonName>
      <signatureDetails>
        <signature>/s/ Marie Karlsfeldt</signature>
        <title>Marie Karlsfeldt / Middle Office</title>
        <date>04/01/2026</date>
      </signatureDetails>
    </signatureInformation>
  </formData>
</edgarSubmission>
