<?xml version="1.0" encoding="UTF-8"?><edgarSubmission xmlns="http://www.sec.gov/edgar/schedule13D" xmlns:com="http://www.sec.gov/edgar/common">
  <headerData>
    <submissionType>SCHEDULE 13D</submissionType>
    <filerInfo>
      <filer>
        <filerCredentials>
          <!-- Field: Pseudo-Tag; ID: Name; Data: Jung Hyunsu -->
          <cik>0002075658</cik>
          <ccc>XXXXXXXX</ccc>
        </filerCredentials>
      </filer>
      <liveTestFlag>LIVE</liveTestFlag>


    </filerInfo>
  </headerData>
  <formData>
    <coverPageHeader>
      <securitiesClassTitle>Common Stock, $0.0001 par value</securitiesClassTitle>
      <dateOfEvent>06/17/2025</dateOfEvent>
      <previouslyFiledFlag>false</previouslyFiledFlag>
      <issuerInfo>
        <issuerCIK>0001682639</issuerCIK>
        <issuerCUSIP>30234E203</issuerCUSIP>
        <issuerName>Hyperion DeFi, Inc.</issuerName>
        <address>
          <com:street1>23461 South Pointe Drive</com:street1>
          <com:street2>Suite 390</com:street2>
          <com:city>Laguna Hills</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92653</com:zipCode>
        </address>
      </issuerInfo>
      <authorizedPersons>
        <notificationInfo>
          <personName>Hyunsu Jung</personName>
          <personPhoneNum>(833) 393-6684</personPhoneNum>
          <personAddress>
            <com:street1>23461 South Pointe Drive</com:street1>
            <com:street2>Suite 390</com:street2>
            <com:city>Laguna Hills</com:city>
            <com:stateOrCountry>CA</com:stateOrCountry>
            <com:zipCode>92653</com:zipCode>
          </personAddress>
        </notificationInfo>
      </authorizedPersons>
    </coverPageHeader>
    <reportingPersons>
      <reportingPersonInfo>
        <reportingPersonCIK>0002075658</reportingPersonCIK>
        <reportingPersonNoCIK>N</reportingPersonNoCIK>
        <reportingPersonName>Hyunsu Jung</reportingPersonName>
        <fundType>SC</fundType>
        <legalProceedings>N</legalProceedings>
        <citizenshipOrOrganization>X1</citizenshipOrOrganization>
        <soleVotingPower>500000.00</soleVotingPower>
        <sharedVotingPower>0.00</sharedVotingPower>
        <soleDispositivePower>500000.00</soleDispositivePower>
        <sharedDispositivePower>0.00</sharedDispositivePower>
        <aggregateAmountOwned>500000.00</aggregateAmountOwned>
        <isAggregateExcludeShares>N</isAggregateExcludeShares>
        <percentOfClass>9.3</percentOfClass>
        <typeOfReportingPerson>IN</typeOfReportingPerson>
        <commentContent>(1)  Includes 500,000 shares of Common Stock (defined below).
(2)  Calculated based on 5,361,034 shares of Common Stock outstanding as of July 10, 2025.</commentContent>
      </reportingPersonInfo>
    </reportingPersons>
    <items1To7>
      <item1>
        <securityTitle>Common Stock, $0.0001 par value</securityTitle>
        <issuerName>Hyperion DeFi, Inc.</issuerName>
        <issuerPrincipalAddress>
          <com:street1>23461 South Pointe Drive</com:street1>
          <com:street2>Suite 390</com:street2>
          <com:city>Laguna Hills</com:city>
          <com:stateOrCountry>CA</com:stateOrCountry>
          <com:zipCode>92653</com:zipCode>
        </issuerPrincipalAddress>
        <commentText>This statement on Schedule 13D ("Schedule 13D") relates to shares of common stock, $0.0001 par value (the "Common Stock") of Hyperion DeFi, Inc., a Delaware corporation (the "Issuer"), whose principal executive offices are located at 23461 South Pointe Drive, Suite 390, Laguna Hills, CA 92653.</commentText>
      </item1>
      <item2>
        <filingPersonName>This Schedule 13D is filed by Hyunsu Jung, who is referred to herein as the "Reporting Person."</filingPersonName>
        <principalBusinessAddress>The Reporting Person's address is c/o Hyperion DeFi, Inc., 23461 South Pointe Drive, Suite 390, Laguna Hills, CA 92653.</principalBusinessAddress>
        <principalJob>The Reporting Person is the Chief Investment Officer and a Director of Hyperion DeFi, Inc.</principalJob>
        <hasBeenConvicted>During the last five years, the Reporting Person has not been convicted in a criminal proceeding (excluding traffic violations or similar misdemeanors).</hasBeenConvicted>
        <convictionDescription>During the last five years, the Reporting Person has not been a party to a civil proceeding of a judicial or administrative body of competent jurisdiction and as a result of such proceeding was or is subject to a judgment, decree or final order enjoining future violations of, or prohibiting or mandating activities subject to, federal or state securities laws or finding any violation with respect to such laws.</convictionDescription>
        <citizenship>United States of America.</citizenship>
      </item2>
      <item3>
        <fundsSource>The 500,000 shares of Common Stock were acquired by the Reporting Person pursuant to the Employment Agreement between the Reporting Person and the Issuer, dated June 17, 2025 (the "Employment Agreement"), as an inducement to accept employment with the Issuer.

A copy of the Employment Agreement is filed as Exhibit 99.1 to this Schedule 13D and is incorporated herein by reference.</fundsSource>
      </item3>
      <item4>
        <transactionPurpose>(a)-(j). The shares of Common Stock beneficially owned by the Reporting Person have been acquired for investment purposes and were not acquired with the intent to change or influence control of the Issuer or to participate in any transaction having that purpose or effect. The Reporting Person reserves the right to change his plan and intentions at any time as he deems appropriate.

Pursuant to the Employment Agreement, the Issuer committed to issue an additional 1,000,000 shares of Common Stock to Mr. Jung upon the vesting of restricted stock units (the "RSUs") that were granted to Mr. Jung subject to and upon any necessary approvals by the Issuer's stockholders and the Issuer's board of directors and the terms of the Company's 2018 Omnibus Stock Incentive Plan, as amended. The RSUs vest as follows: 500,000 shares will vest upon the Company achieving a market capitalization of $150,000,000, and the remaining 500,000 shares will vest upon the Company achieving a market capitalization of $500,000,000. The Reporting Person may acquire additional shares of Common Stock, dispose of all or some of his shares of Common Stock from time to time, in each case in the open market or private transactions, block sales or purchases or otherwise, or may continue to hold the shares of Common Stock, depending on business and market conditions, and other factors.

Other than as set forth above, the Reporting Person has no plans or proposals which would relate or result in any of the matters set forth in subparagraphs (a) - (j) of Item 4 of Schedule 13D except as set forth herein.</transactionPurpose>
      </item4>
      <item5>
        <percentageOfClassSecurities>The aggregate number and percentage of Common Stock beneficially owned by the Reporting Person (on the basis of a total of 5,304,868 shares of Common Stock outstanding as of July 8, 2025) are as follows:

Amount beneficially owned: 500,000                                          Percentage: 9.3%</percentageOfClassSecurities>
        <numberOfShares>Number of shares to which the Reporting Person has:

      i.   Sole power to vote or to direct the vote:                                500,000(1)
      ii.  Shared power to vote or to direct the vote:                             0
      iii. Sole power to dispose or to direct the disposition of:            500,000(1)
      iv. Shared power to dispose or to direct the disposition of:         0

   (1) Includes 500,000 shares of Common Stock acquired by the Reporting Person pursuant to the Employment Agreement, as an inducement to accept employment with the Issuer.</numberOfShares>
        <transactionDesc>The required transaction described in this Item 5(a) was reported on a Form 4 filed by Mr. Jung with the SEC pursuant to Section 16 of the Act, which is available on the SEC's website at www.sec.gov. The information reported in such filing is expressly incorporated herein.</transactionDesc>
        <listOfShareholders>Not applicable.</listOfShareholders>
        <date5PercentOwnership>Not applicable.</date5PercentOwnership>
      </item5>
      <item6>
        <contractDescription>Not applicable.</contractDescription>
      </item6>
      <item7>
        <filedExhibits>Exhibit 99.1  Executive Employment Agreement by and between Eyenovia, Inc. and Hyunsu Jung, dated June 17, 2025 (incorporated by reference to Exhibit 10.4 to the Current Report on Form 8-K filed with the Securities and Exchange Commission on June 24, 2025 (File No. 001- 38365)).</filedExhibits>
      </item7>
    </items1To7>
    <signatureInfo>
      <signaturePerson>
        <signatureReportingPerson>Hyunsu Jung</signatureReportingPerson>
        <signatureDetails>
          <signature>/s/ Hyunsu Jung</signature>
          <title>Hyunsu Jung</title>
          <date>07/16/2025</date>
        </signatureDetails>
      </signaturePerson>
    </signatureInfo>
  </formData>
</edgarSubmission>
