X0306 4 2019-11-19 0 0001674416 CRISPR Therapeutics AG CRSP 0001682017 Novak Rodger C/O CRISPR THERAPEUTICS, INC. 610 MAIN STREET CAMBRIDGE MA 02139 1 1 0 0 President Common Shares 2019-11-19 4 M 0 33618 14.43 A 33618 D Common Shares 2019-11-19 4 S 0 33618 70.00 D 0 D Stock Option (Right to Buy) 14.43 2019-11-19 4 M 0 33618 0.00 D 2024-01-15 Common Shares 33618 236382 D The sales reported in this Form 4 were effected pursuant to a Rule 10b5-1 trading plan adopted by the reporting person. 270,000 options to purchase common shares were granted on June 15, 2017 and originally vested in 48 equal monthly installments commencing upon the grant date. Pursuant to Dr. Novak's amended and restated employment agreement with the Company, subject to his continued employment, beginning November 30, 2018, the remaining unvested options from this grant vest in equal monthly installments at the rate of 50% of the amounts originally scheduled to vest on any one vesting date, and the original vesting schedule was extended to reflect the amended schedule. /s/ Michael Esposito, attorney-in-fact 2019-11-21