X0206 3 2016-10-18 0 0001674416 CRISPR Therapeutics AG CRSP 0001682017 Novak Rodger C/O CRISPR THERAPEUTICS, INC. 200 SIDNEY STREET CAMBRIDGE MA 02139 1 1 0 0 Chief Executive Officer Common Shares 1215005 D Stock Options (Right to Buy) 1.81 2025-09-10 Common Shares 268093 D This option was granted on September 10, 2015 with respect to 268,093 Common Shares with 94,950 shares immediately vested on the grant date and the remaining 173,143 shares vest in 31equal monthly installments thereafter. /s/ Rodger Novak 2016-10-18