<?xml version="1.0"?>
<ownershipDocument>

    <schemaVersion>X0607</schemaVersion>

    <documentType>3</documentType>

    <periodOfReport>2026-10-01-05:00</periodOfReport>

    <noSecuritiesOwned>0</noSecuritiesOwned>

    <issuer>
        <issuerCik>0001681682</issuerCik>
        <issuerName>ENDRA Life Sciences Inc.</issuerName>
        <issuerTradingSymbol>NDRA</issuerTradingSymbol>
        <issuerForeignTradingSymbol></issuerForeignTradingSymbol>
    </issuer>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0001921865</rptOwnerCik>
            <rptOwnerName>ASP Isotopes Inc.</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>false</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>2200 ROSS AVENUE, SUITE 4575E</rptOwnerStreet1>
            <rptOwnerStreet2></rptOwnerStreet2>
            <rptOwnerCity>DALLAS</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>75201</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>true</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <reportingOwner>
        <reportingOwnerId>
            <rptOwnerCik>0002157843</rptOwnerCik>
            <rptOwnerName>LHE LNG Holdings LLC</rptOwnerName>
        </reportingOwnerId>
        <reportingOwnerAddress>
            <rptOwnerNonUSAddressFlag>false</rptOwnerNonUSAddressFlag>
            <rptOwnerStreet1>2200 ROSS AVENUE</rptOwnerStreet1>
            <rptOwnerStreet2>SUITE 4575E</rptOwnerStreet2>
            <rptOwnerCity>DALLAS</rptOwnerCity>
            <rptOwnerState>TX</rptOwnerState>
            <rptOwnerZipCode>75201</rptOwnerZipCode>
            <rptOwnerStateDescription></rptOwnerStateDescription>
        </reportingOwnerAddress>
        <reportingOwnerRelationship>
            <isDirector>false</isDirector>
            <isOfficer>false</isOfficer>
            <isTenPercentOwner>true</isTenPercentOwner>
            <isOther>false</isOther>
        </reportingOwnerRelationship>
    </reportingOwner>

    <nonDerivativeTable>
        <nonDerivativeHolding>
            <securityTitle>
                <value>Common Stock</value>
            </securityTitle>
            <postTransactionAmounts>
                <sharesOwnedFollowingTransaction>
                    <value>66846</value>
                    <footnoteId id="F1"/>
                </sharesOwnedFollowingTransaction>
            </postTransactionAmounts>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By LHE LNG Holdings LLC</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </nonDerivativeHolding>
    </nonDerivativeTable>

    <derivativeTable>
        <derivativeHolding>
            <securityTitle>
                <value>Pre-Funded Warrants</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>0.0001</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F3"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F3"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>511541</value>
                    <footnoteId id="F3"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By LHE LNG Holdings LLC</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
        <derivativeHolding>
            <securityTitle>
                <value>Warrants</value>
            </securityTitle>
            <conversionOrExercisePrice>
                <value>6.57</value>
            </conversionOrExercisePrice>
            <exerciseDate>
                <footnoteId id="F4"/>
            </exerciseDate>
            <expirationDate>
                <footnoteId id="F4"/>
            </expirationDate>
            <underlyingSecurity>
                <underlyingSecurityTitle>
                    <value>Common Stock</value>
                </underlyingSecurityTitle>
                <underlyingSecurityShares>
                    <value>1156774</value>
                    <footnoteId id="F4"/>
                </underlyingSecurityShares>
            </underlyingSecurity>
            <ownershipNature>
                <directOrIndirectOwnership>
                    <value>I</value>
                </directOrIndirectOwnership>
                <natureOfOwnership>
                    <value>By LHE LNG Holdings LLC</value>
                    <footnoteId id="F2"/>
                </natureOfOwnership>
            </ownershipNature>
        </derivativeHolding>
    </derivativeTable>

    <footnotes>
        <footnote id="F1">Represents 66,846 shares of common stock, par value $0.0001 per share (the &quot;Common Stock&quot;), of ENDRA Life Sciences Inc. (the &quot;Issuer&quot;), held by LHE LNG Holdings LLC (&quot;LHE LNG&quot;), a wholly owned subsidiary of ASP Isotopes Inc. (the &quot;ASP Isotopes&quot;).</footnote>
        <footnote id="F2">Represents securities held by LHE LNG. ASP Isotopes controls LHE LNG and may be deemed to beneficially own securities of the Issuer held by LHE LNG. ASP Isotopes and LHE LNG each disclaims beneficial ownership of such securities except to the extent of their respective pecuniary interest therein. This report shall not be deemed an admission that ASP Isotopes or LHE LNG is the beneficial owner of such securities for purposes of Sections 13 and 16 of the Securities Exchange Act of 1934, as amended, or for any other purpose.</footnote>
        <footnote id="F3">Represents pre-funded warrants to purchase up to (i) 187,169 shares of Common Stock of the Issuer held by LHE LNG exercisable within 60 days of the date hereof and (ii) 324,372 shares of Common Stock of the Issuer held by LHE LNG exercisable on or after the date that the Issuer obtains stockholder approval of the issuance of the shares of Common Stock underlying the pre-funded warrants and warrants reported herein (the &quot;Stockholder Approval&quot;). The pre-funded warrants do not expire.</footnote>
        <footnote id="F4">Represents warrants to purchase an aggregate of up to 1,156,774 shares of Common Stock at an exercise price of $6.57 held by LHE LNG, which are not exercisable until Stockholder Approval is obtained. The warrants expire on May 27, 2031.</footnote>
    </footnotes>

    <ownerSignature>
        <signatureName>ASP Isotopes Inc., By: /s/ Donald G. Ainscow, Name: Donald G. Ainscow, Title: Executive Vice President, General Counsel and Secretary</signatureName>
        <signatureDate>2026-10-08</signatureDate>
    </ownerSignature>

    <ownerSignature>
        <signatureName>LHE LNG Holdings LLC, By: /s/  Donald G. Ainscow, Title: Donald G. Ainscow, Executive Vice President, General Counsel and Secretary</signatureName>
        <signatureDate>2026-10-08</signatureDate>
    </ownerSignature>
</ownershipDocument>
