SCHEDULE 13G 0001758866 XXXXXXXX LIVE Common Stock, $0.0001 par value per share 02/15/2024 0001681087 AVROBIO, Inc. 05455M100 100 TECHNOLOGY SQUARE 6TH FLOOR CAMBRIDGE MA 02139 Rule 13d-1(c) ADAR1 Partners, LP DE 0.00 3276498.00 0.00 3276498.00 3276498.00 7.4 PN ADAR1 Capital Management, LLC TX 0.00 3276498.00 0.00 3276498.00 3276498.00 7.4 OO ADAR1 Capital Management, LLC acts as an investment adviser to, and manages investment and trading accounts of, ADAR1 Partners, LP. ADAR1 Capital Management, LLC may be deemed to indirectly beneficially own securities held by ADAR1 Partners, LP. ADAR1 Capital Management GP, LLC TX 0.00 3276498.00 0.00 3276498.00 3276498.00 7.4 OO ADAR1 Capital Management GP, LLC acts as the general partner of ADAR1 Partners, LP. ADAR1 Capital Management GP, LLC may be deemed to indirectly beneficially own securities held by ADAR1 Partners, LP. Daniel Schneeberger V8 0.00 3276498.00 0.00 3276498.00 3276498.00 7.4 IN ADAR1 Capital Management, LLC acts as an investment adviser to, and manages investment and trading accounts of, ADAR1 Partners, LP. ADAR1 Capital Management GP, LLC acts as the general partner of ADAR1 Partners, LP. Mr. Schneeberger is the Manager of ADAR1 Capital Management, LLC and ADAR1 Capital Management GP, LLC. Mr. Schneeberger may be deemed to indirectly beneficially own securities held by ADAR1 Partners, LP. AVROBIO, Inc. 100 TECHNOLOGY SQUARE, 6TH FLOOR, CAMBRIDGE, MASSACHUSETTS, 02139 This Schedule is being filed on behalf of each of the following persons (each, a "Reporting Person" and collectively, the "Reporting Persons") i) ADAR1 Partners, LP ("ADAR1 Fund"); ii) ADAR1 Capital Management, LLC ("ADAR1 Capital Management"); iii) ADAR1 Capital Management GP, LLC ("ADAR1 General Partner"); and iv) Daniel Schneeberger ("Mr. Schneeberger") This Schedule relates to shares of common stock of the Issuer, par value $0.0001 per share ("Shares"), directly held by ADAR1 Fund. ADAR1 Capital Management acts as an investment adviser to, and manages investment and trading accounts of, ADAR1 Fund. ADAR1 General Partner acts as the general partner of ADAR1 Fund. ADAR1 Capital Management and ADAR1 General Partner may be deemed to indirectly beneficially own securities held by ADAR1 Fund. Mr. Schneeberger is the Manager of ADAR1 Capital Management and ADAR1 General Partner. Mr. Schneeberger may be deemed to indirectly beneficially own securities held by ADAR1 Fund. Each Reporting Person declares that neither the filing of this Schedule nor anything herein shall be construed as an admission that such person is, for the purposes of Section 13(d) or 13(g) of the Act or any other purpose, (i) acting (or has agreed or is agreeing to act) with any other person as a partnership, limited partnership, syndicate, or other group for the purpose of acquiring, holding, or disposing of securities of the Issuer or otherwise with respect to the Issuer or any securities of the Issuer or (ii) a member of any syndicate or group with respect to the Issuer or any securities of the Issuer. The address of the principal business office of each of the Reporting Persons is 3503 Wild Cherry Drive, Building 9, Austin, Texas 78738. i) ADAR1 Fund is a Delaware limited partnership; ii) ADAR1 Capital Management is a Texas limited liability company; iii) ADAR1 General Partner is a Texas limited liability company; and iv) Mr. Schneeberger is a citizen of Switzerland. Y As of the date hereof, each of the Reporting Persons may be deemed to be the beneficial owner of 3,276,498 Shares. As of the date hereof, each of the Reporting Persons may be deemed to be the beneficial owner of approximately 7.4% of the Shares outstanding, based on 44,573,911 Shares outstanding as of November 2, 2023, as reported in the Issuer's Quarterly Report on Form 10-Q filed with the Securities and Exchange Commission on November 9, 2023. 0 3,276,498 0 3,276,498 Y N Y Y Y Y N By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect, other than activities solely in connection with a nomination under § 240.14a-11. ADAR1 Partners, LP Daniel Schneeberger 02/23/2024 ADAR1 Capital Management, LLC Daniel Schneeberger 02/23/2024 ADAR1 Capital Management GP, LLC Daniel Schneeberger 02/23/2024 Daniel Schneeberger Daniel Schneeberger 02/23/2024 Joint_Filing_Agreement.htm EX-1 Joint Filing Agreement PEhUTUw+DQo8SEVBRD4NCiAgICAgPFRJVExFPjwvVElUTEU+DQo8L0hFQUQ+DQo8Qk9EWSBT VFlMRT0iZm9udDogMTBwdCBUaW1lcyBOZXcgUm9tYW4sIFRpbWVzLCBTZXJpZiI+DQoNCjxQ IFNUWUxFPSJmb250OiAxMXB0IFRpbWVzIE5ldyBSb21hbiwgVGltZXMsIFNlcmlmOyBtYXJn aW46IDA7IHRleHQtYWxpZ246IGNlbnRlciI+PEI+RVhISUJJVCBBPC9CPjwvUD4NCg0KPFAg U1RZTEU9ImZvbnQ6IDExcHQgVGltZXMgTmV3IFJvbWFuLCBUaW1lcywgU2VyaWY7IG1hcmdp bjogMDsgdGV4dC1hbGlnbjogY2VudGVyIj48Qj4mbmJzcDs8L0I+PC9QPg0KDQo8UCBTVFlM RT0iZm9udDogMTFwdCBUaW1lcyBOZXcgUm9tYW4sIFRpbWVzLCBTZXJpZjsgbWFyZ2luOiAw IDAgMTJwdDsgdGV4dC1hbGlnbjogY2VudGVyIj48Qj5KT0lOVCBGSUxJTkcgQUdSRUVNRU5U PEJSPjwvQj48L1A+DQoNCjxQIFNUWUxFPSJmb250OiAxMXB0IFRpbWVzIE5ldyBSb21hbiwg 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