Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2023	Dec. 31, 2022
Income Taxes Disclosure [Line Items]
Increase in valuation allowance	$ 35,000,000
Orphan drug credit carryforwards	$ 14,628,000	$ 23,790,000
Open tax year	2016 2017 2018 2019 2020
Accrued interest related to uncertain tax positions	$ 0	0
Accrued penalties related to uncertain tax positions	0	0
Penalties and interest expense related to income taxes	0	$ 0
Federal
Income Taxes Disclosure [Line Items]
Net operating loss carryforwards	$ 312,300,000
Net operating loss carryforwards expiration beginning year	2036
Net operating loss carryforwards indefinitely	$ 288,700,000
Tax credit carryforwards, Expiration year	2040
Orphan drug credit carryforwards	$ 23,800,000
Federal | Research and Development
Income Taxes Disclosure [Line Items]
Tax credit carryforwards	$ 6,000,000
Tax credit carryforwards, Expiration year	2035
State
Income Taxes Disclosure [Line Items]
Net operating loss carryforwards	$ 317,100,000
Net operating loss carryforwards expiration beginning year	2036
State | Research and Development
Income Taxes Disclosure [Line Items]
Tax credit carryforwards	$ 4,900,000
Tax credit carryforwards, Expiration year	2030