Income Taxes - Additional Information (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
Income Taxes Disclosure [Line Items]
Increase in valuation allowance	$ 34,900,000
Orphan drug credit carryforwards	$ 14,628,000	$ 6,679,000
Open tax year	2016 2017 2018 2019 2020
Accrued interest related to uncertain tax positions	$ 0	0
Accrued penalties related to uncertain tax positions	0	0
Penalties and interest expense related to income taxes	0
Federal
Income Taxes Disclosure [Line Items]
Net operating loss carryforwards	$ 275,100,000
Net operating loss carryforwards expiration beginning year	2036
Net operating loss carryforwards indefinitely	$ 251,500,000
Tax credit carryforwards, Expiration year	2040
Orphan drug credit carryforwards	$ 14,600,000
Federal | Research and Development
Income Taxes Disclosure [Line Items]
Tax credit carryforwards		$ 6,900,000
Tax credit carryforwards, Expiration year	2035
State
Income Taxes Disclosure [Line Items]
Net operating loss carryforwards	$ 272,600,000
Net operating loss carryforwards expiration beginning year	2036
State | Research and Development
Income Taxes Disclosure [Line Items]
Tax credit carryforwards	$ 4,000,000.0
Tax credit carryforwards, Expiration year	2030